Adam Santoro

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The structure-guided design of chloride-conducting channelrhodopsins has illuminated mechanisms underlying ion selectivity of this remarkable family of light-activated ion channels. The first generation of chloride-conducting channelrhodopsins, guided in part by development of a structure-informed electrostatic model for pore selectivity, included both the(More)
Memories are not static but continue to be processed after encoding. This is thought to allow the integration of related episodes via the identification of patterns. Although this idea lies at the heart of contemporary theories of systems consolidation, it has yet to be demonstrated experimentally. Using a modified water-maze paradigm in which platforms are(More)
Despite recent breakthroughs in the applications of deep neural networks, one setting that presents a persistent challenge is that of " one-shot learning. " Traditional gradient-based networks require a lot of data to learn, often through extensive iterative training. When new data is encountered, the models must inefficiently relearn their parameters to(More)
Despite recent breakthroughs in the applications of deep neural networks, one setting that presents a persistent challenge is that of " one-shot learning. " Traditional gradient-based networks require a lot of data to learn, often through extensive iterative training. When new data is encountered, the models must inefficiently relearn their parameters to(More)
Event memories are stored in hippocampal-cortical networks. In this issue of Neuron, two studies, Cowansage et al. (2014) and Tanaka et al. (2014), tag active cells during memory encoding and optogenetically manipulate the activity of these "engram" cells during subsequent recall to reveal how hippocampal and cortical cell ensembles interact during(More)
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