Adam Rosenthal

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We present a novel microfabricated dielectrophoretic trap designed to pattern large arrays of single cells. Because flowing away untrapped cells is often the rate-limiting step during cell patterning, we designed the trap to be strong enough to hold particles against practical flow rates. We experimentally validated the trap strength by measuring the(More)
We present a novel technique to accurately position single cells on a substrate using negative dielectrophoresis and cell-substrate adhesion. The cells are suspended in physiological media throughout the patterning process. We also verify the biocompatibility of this method by demonstrating that the patterned cells proliferate and show normal morphology. We(More)
We present quantitative modeling software for simulating multiple forces acting on a single particle in a microsystem. In this paper, we focus on dielectrophoretic (DEP) trapping of single cells against fluid flow. The software effectively models the trapping behavior for a range of particles including beads, mammalian cells, viruses, and bacteria. In(More)
Gene expression profiling (GEP) via microarray analysis is a widely used tool for assessing risk and other patient diagnostics in clinical settings. However, non-biological factors such as systematic changes in sample preparation, differences in scanners, and other potential batch effects are often unavoidable in long-term studies and meta-analysis. In(More)
We have developed a novel nDEP trap designed to pattern single cells. We tested the strength of our traps using polystyrene beads and the measurements were found to be in excellent agreement with our modeling predictions. Our DEP traps display a tunable peak size-selectivity behavior, with these traps being optimized to trap particles of ~12 µm. Finally, we(More)
  • Lauren Lebon, Michelle Fontes, Tara Orr, Jonathan Young, Joe Levine, Fred Tan +33 others
  • 2014
Acknowledgments I must start with thanking my advisor, Michael Elowitz. His sheer enthusiasm and uncanny knack for finding cool scientific questions have made life in the Labowitz a constant adventure. Michael gives his team the freedom to follow whatever ideas we find exciting. He then teaches us the skills and gives us the opportunities to convey our(More)
Our group performs research on BioMEMS, applying microfabrication technology to illuminate biological systems, especially at the cellular level. Specifically, we develop technologies that are used to manipulate cells or make measurements from them. Our research builds upon various disciplines: electrical engineering, microfabrication, bioengineering,(More)
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