Adam R. Hersperger

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Many immune correlates of CD8(+) T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor expression, have been discovered. However, no functional correlates using ex vivo cells have been identified with the known ability to cause the direct elimination of HIV-infected cells. We have recently(More)
The prevailing paradigm of T lymphocyte control of viral replication is that the protective capacity of virus-specific CD8(+) T cells is directly proportional to the number of functions they can perform, with IL-2 production capacity considered critical. Having recently defined rapid perforin upregulation as a novel effector function of antigen-specific(More)
As a group, poxviruses have been shown to infect a wide variety of animal species. However, there is individual variability in the range of species able to be productively infected. In this study, we observed that ectromelia virus (ECTV) does not replicate efficiently in cultured rabbit RK13 cells. Conversely, vaccinia virus (VACV) replicates well in these(More)
CD8+ T cells are often referred to as cytotoxic T lymphocytes because of their ability to induce the apoptosis of cells infected with an intracellular pathogen, thereby limiting the spread of an infection to previously uninfected cells. CD8+ T cells produce many proteins-including perforin, various granzymes, and granulysin-that are responsible for inducing(More)
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