Adam Morgenthaler

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Hippocampal neurogenesis, the product of resident neural stem cell proliferation and differentiation, persists into adulthood but decreases with organismal aging, which may contribute to the age-related decline in cognitive function. The mechanisms that underlie this decrease in neurogenesis are not well understood, although evidence in general indicates(More)
Stem cell function declines with age largely due to the biochemical imbalances in their tissue niches, and this work demonstrates that aging imposes an elevation in transforming growth factor β (TGF-β) signaling in the neurogenic niche of the hippocampus, analogous to the previously demonstrated changes in the myogenic niche of skeletal muscle with age.(More)
Hippocampal neurogenesis, the product of resident neural stem cell proli‐ feration and differentiation, persists into adulthood but decreases with organismal aging, which may contribute to the age‐related decline in cog‐ nitive function. The mechanisms that underlie this decrease in neurogene‐ sis are not well understood, though evidence in(More)
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