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Nuclear processes such as transcription, DNA replication and recombination are dynamically regulated by chromatin structure. Eukaryotic transcription is known to be regulated by chromatin-associated proteins containing conserved protein domains that specifically recognize distinct covalent post-translational modifications on histones. However, it has been(More)
The preferential in vitro interaction of the PHD finger of RAG2, a subunit of the V(D)J recombinase, with histone H3 tails simultaneously trimethylated at lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2sK4me3) predicted the existence of the previously unknown histone modification H3R2me2s. Here, we report the in vivo identification of(More)
Each V, D, and J gene segment is flanked by a recombination signal sequence (RSS), composed of a conserved heptamer and nonamer separated by a 12- or 23-bp spacer. Variations from consensus in the heptamer or nonamer at specific positions can dramatically affect recombination frequency, but until recently, it had been generally held that only the length of(More)
The aftermath of a natural disaster is characterized by lack of a reliable medium for dissemination of information to survivors. The state-of-the-art emergency response systems rely on satellite radio-enabled devices, but survivors, unlike first responders, do not have access to such devices. To mitigate this problem, we present perpetuu, a solar-powered(More)
The Advanced Encryption Standard (AES) has been widely used in many applications since adopted by the NIST in 2001. AES is often implemented in hardware for security purposes, but because of the complex nature of the algorithm, reliability is a major concern. The use of error-detecting codes (EDCs) and physical duplication are generally the two methods that(More)
Omenn syndrome is a primary immunodeficiency disorder, featuring susceptibility to infections and autoreactive T cells and resulting from defective genomic rearrangement of genes for the T cell and B cell receptors. The most frequent etiologies are hypomorphic mutations in "non-core" regions of the Rag1 or Rag2 genes, the protein products of which are(More)
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