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The conserved transcriptional regulator heat shock factor 1 (Hsf1) is a key sensor of proteotoxic and other stress in the eukaryotic cytosol. We surveyed Hsf1 activity in a genome-wide loss-of-function library in Saccaromyces cerevisiae as well as ~78,000 double mutants and found Hsf1 activity to be modulated by highly diverse stresses. These included(More)
Which region of the visual field is most useful for recognizing scene gist, central vision (the fovea and parafovea) based on its higher visual resolution and importance for object recognition, or the periphery, based on resolving lower spatial frequencies useful for scene gist recognition, and its large extent? Scenes were presented in two experimental(More)
What information do people use to categorize scenes? Computational scene classification models have proposed that unlocalized amplitude information, the distribution of spatial frequencies and orientations, is useful for categorizing scenes. Previous research has provided conflicting results regarding this claim. Our previous research (Loschky et al., 2007)(More)
Blur detection is affected by retinal eccentricity, but is it also affected by attentional resources? Research showing effects of selective attention on acuity and contrast sensitivity suggests that allocating attention should increase blur detection. However, research showing that blur affects selection of saccade targets suggests that blur detection may(More)
What is the relationship between film viewers' eye movements and their film comprehension? Typical Hollywood movies induce strong attentional synchrony-most viewers look at the same things at the same time. Thus, we asked whether film viewers' eye movements would differ based on their understanding-the mental model hypothesis-or whether any such differences(More)
Viewers can rapidly extract a holistic semantic representation of a real-world scene within a single eye fixation, an ability called recognizing the gist of a scene, and operationally defined here as recognizing an image's basic-level scene category. However, it is unknown how scene gist recognition unfolds over both time and space-within a fixation and(More)
This study investigated the relative roles of visuospatial versus linguistic working memory (WM) systems in the online generation of bridging inferences while viewers comprehend visual narratives. We contrasted these relative roles in the visuospatial primacy hypothesis versus the shared (visuospatial & linguistic) systems hypothesis, and tested them in 3(More)
Using a ScanMatch algorithm we investigate scan path differences between subjects who answer physics problems correctly and incorrectly. This algorithm bins a saccade sequence spatially and temporally, recodes this information to create a sequence of letters representing fixation location, duration and order, and compares two sequences to generate a(More)
How are visual scenes represented in the brain during cat-egorization? We acquired magnetoencephalography (MEG) data from nine healthy subjects who participated in a rapid natural scene catego-rization task. Scenes were presented in two different perspectives (aerial vs. terrestrial) and two different orientations (upright vs. inverted). We applied(More)
When comprehending a film, viewers rapidly construct a working memory representation of the narrative called an event model. These models encode the story location first (Kitchen vs. Park) followed by the character's action (Cooking vs. Washing dishes)(Larson, Hendry, & Loschky, 2012). This time course for scene and action categorization was also supported(More)