Adam Klipfel

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PURPOSE To evaluate the feasibility and pathologic complete response rate of induction bevacizumab + modified infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX) 6 regimen followed by concurrent bevacizumab, oxaliplatin, continuous infusion 5-fluorouracil (5-FU), and radiation for patients with rectal cancer. METHODS AND MATERIALS Eligible(More)
The molecular mechanisms involved in progression of squamous cell carcinoma of the anus (SCCA) are poorly elucidated, as well as the potential role of HIV infection. Loss of heterozygosity (LOH) is one of the mechanisms responsible for inactivation of tumor suppressor genes. We hypothesized that HIV-induced immunosuppression may contribute to an alternate(More)
Alvimopan, a peripherally acting Mu-opioid receptor antagonist, has been shown to enhance recovery of gastrointestinal (GI) function in open bowel resection. The aim of this study was to determine the effect of Alvimopan on patients undergoing laparoscopic right colectomies in preventing postoperative ileus (POI). A prospective, nonrandomized trial of(More)
PURPOSE Following preoperative chemoradiation and surgery, many patients with stage II to III rectal cancer are unable to tolerate full-dose adjuvant chemotherapy. BrUOG R-224 was designed to assess the impact of COmplete Neoadjuvant Treatment for REctal cancer (CONTRE), primary chemotherapy followed by chemoradiation and surgery, on treatment delivery,(More)
This text, like the two previous editions, provides the reader with relevant, procedure-specific, operative anatomy, including potential complications and safety elements. It includes more than 110 procedures, both open and laparoscopic, from all areas of the body. This text will be useful for surgeons from all specialty areas but especially for the general(More)
I thank the authors for an excellent review and series of patients on the topic of perineal/buttocks hidradenitis and its management. The authors discussed the management of severe stage III hidradenitis, which consists of diffuse involvement with multiple interconnected tracts and abscesses [1]. The article describes using a full excision technique to(More)
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