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Analysis of protein-coding genetic variation in 60,706 humans
Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis ofExpand
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An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may induce mutation clustersExpand
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The genetic landscape of high-risk neuroblastoma
Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine theExpand
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Mutational heterogeneity in cancer and the search for new cancer genes
Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve theExpand
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Automatic creation of SQL Injection and cross-site scripting attacks
We present a technique for finding security vulnerabilities in Web applications. SQL Injection (SQLI) and cross-site scripting (XSS) attacks are widespread forms of attack in which the attackerExpand
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HAMPI: a solver for string constraints
Many automatic testing, analysis, and verification techniques for programs can be effectively reduced to a constraint generation phase followed by a constraint-solving phase. This separation ofExpand
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Whole-exome sequencing and clinical interpretation of formalin-fixed , paraffin-embedded tumor samples to guide precision cancer medicine
682 VOLUME 20 | NUMBER 6 | JUNE 2014 naTuRe medicine Translating whole-exome sequencing (WES) for prospective clinical use may have an impact on the care of patients with cancer; however, multipleExpand
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Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes
Detection of somatic mutations in human leukocyte antigen (HLA) genes using whole-exome sequencing (WES) is hampered by the high polymorphism of the HLA loci, which prevents alignment of sequencingExpand
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Grammar-based whitebox fuzzing
Whitebox fuzzing is a form of automatic dynamic test generation, based on symbolic execution and constraint solving, designed for security testing of large applications. Unfortunately, the currentExpand
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Genome sequencing reveals insights into physiology and longevity of the naked mole rat
The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, makingExpand
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