Adam Kashishian

Learn More
GS-1101 (CAL-101) is an oral PI3K␦-specific inhibitor that has shown preclini-cal and clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leu-kemia. To investigate the potential role of PI3K␦ in Hodgkin lymphoma (HL), we screened 5 HL cell lines and primary samples from patients with HL for PI3K␦ isoform expression and constitutive PI3K(More)
Targeting of protein kinases and phosphatases provides additional specificity to substrate selectivity in cellular signaling. In the case of the Ca2+/calmodulin-dependent protein phosphatase calcineurin, AKAP79 has been shown to bind calcineurin and inhibit its activity in vitro (Coghlan, V., Perrino, B. A., Howard, M., Langeberg, L. K., Hicks, J. B.,(More)
  • 1