Adam Johnston

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BACKGROUND AND PURPOSE The objective of this study was to determine whether levetiracetam (LEV) is an effective drug for treatment of trigeminal neuralgia (TN). METHODS Ten patients with TN were enrolled in a 10-week, prospective, open-label pilot study. The primary outcome measure was the visual analogue scale on daily pain diary and side effects. Serum(More)
The disposition of 5-fluorouracil (FUra) was studied in 19 colorectal cancer patients during treatment with FUra and high-dose leucovorin (LV) with or without interferon alpha 2a (IFN-alpha). All received LV 200 mg m-2 over 2 h, then FUra 400 mg m-2 over 5 min then FUra 400 mg m-2 over 22 h, repeated on day 2, on a 14 day cycle. Nine patients also received(More)
The management of congenital adrenal hyperplasia due to 21-hydroxylase (CYP21) deficiency requires glucocorticoid substitution with oral hydrocortisone given twice or thrice daily. In paediatric practice little is known of the bioavailability of oral hydrocortisone tablets used in these patients. The aim of this study was to assess the bioavailability of(More)
The disposition of 5-fluorouracil (FUra) was studied in 19 colorectal cancer patients dunrng treatment with FUra and high-dose leucovorin (LV) with or without interferon x2a (IFN-a). All received LV 200 mg m-Iover 2 h. then FUra 400 mg m-2 over 5 min then FUra 400 mg m ' over 22 h. repeated on day 2. on a 14 day cycle. Nine patients also received IFN-a 6 MU(More)
There is no information on the effect of food or concurrent drug administration on the bioavailability of oral etoposide, despite the fact that treatment is frequently administered over several days and most often in combination with other cytotoxic agents. The influence of these factors has been studied in 11 patients, receiving combination cytotoxic(More)
UNLABELLED Thrombotic complications arising during the treatment of breast cancer can impact the breast reconstruction pathway. We set out to review the details of cases of thromboembolism occurring during neoadjuvant chemotherapy and peri-operatively to study the impact of the event and its management on subsequent breast reconstruction. METHODS We(More)
It is accepted that a traumatic hip dislocation is a surgical emergency, this holds for the uncommon dislocation of the hip with femoral neck fracture however the surgical dilemma involves head salvage or replacement. This case report describes the method and technique for stabilisation of the rare and challenging isolated posterior hip dislocation with an(More)
Acknowledgments Each article published in Ergo was peer reviewed by a committee of students and faculty from Weber State University, and all of the research abstracts were presented at state, regional, or national conferences by the students who developed them. The staff and faculty advisors of Ergo would like to thank the students and faculty members who(More)
There is no information on the effect of food or concurrent drug administration on the bioavailability of oral etoposide, despite the fact that treatment is frequently administered over several days and most often in combination with other cytotoxic agents. The influence of these factors has been studied in 11 patients, receiving combination cytotoxic(More)
Medifoxamine is a new antidepressant drug which is in clinical use in France and is undergoing clinical investigation elsewhere. We have carried out a study of its tolerance by the intravenous route and have investigated its kinetic parameters by this route. Twelve healthy volunteers received single ascending intravenous doses of medifoxamine 5 to 10 mg.(More)
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