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What determines the decision of an inventor to seek patent protection in a foreign jurisdiction, particularly one where intellectual property rights protection is weak? This paper focuses on competition as a determinant of the patenting decision in the context of the recent foreign patenting surge in China. Using a database that comprises of all patents(More)
BACKGROUND We and others have previously reported significant changes in chloride transport after cationic-lipid-mediated transfer of the cystic fibrosis transmembrane conductance regulator (CFTR) gene to the nasal epithelium of patients with cystic fibrosis. We studied the safety and efficacy of this gene transfer to the lungs and nose of patients with(More)
The success of Japanese manufacturing firms such as Honda and Toyota has renewed attention to the importance of cost reduction on existing products as a source of productivity growth. Using survey data and interviews, this paper explores the determinants of average-cost reduction for a sample of 207 automotive suppliers in the United States and Canada(More)
Infection with respiratory syncytial virus (RSV) is one of the major causes globally of childhood respiratory morbidity and hospitalization. Palivizumab, a humanized monoclonal antibody, has been recommended for high risk infants to prevent severe RSV-associated respiratory illness. This recommendation is based on evidence of efficacy when used under(More)
Ruberman, to my fellow students, and to the kind and supportive staff of the Brandeis Mathematics Department. I would like to thank all my family and friends for their love and encouragement with patience and I wish to express my boundless love to my wife, Arifun Chowdhury. This thesis is dedicated to my parents, Md. Enamul Huq and Mahbub Ara Ummeh Sultana,(More)
We estimate an econometric model of the propensity of firms to engage in research joint ventures (RJVs), in order to explain the recent precipitous decline in RJVs filed with the U.S. Department of Justice. We find that RJV activity is inversely related to the competitive position of U.S. firms in global high-technology industries and that the establishment(More)
BACKGROUND Recent reports have shown evidence of host derived parenchymal engraftment in several human allografts including the lung, leading to speculation that stem cell therapy may be useful for lung repair in diseases such as cystic fibrosis (CF). To date, previous studies have looked at single surgical or autopsy specimens and no longitudinal studies(More)
There is evidence of intestinal inflammation in patients with CF. Intestinal inflammation may negatively impact the nutritional status of patient with CF, which adversely affects pulmonary function and survival. This paper provides an up-to-date review of intestinal inflammation in CF and an evaluation of utility of two specific faecal inflammatory markers(More)
BACKGROUND Non-cystic fibrosis (non-CF) bronchiectasis often starts in childhood with a significant impact on adult morbidity. Little is known about disease progression through childhood and the effect on growth and spirometry. This study reviews longitudinal lung function and growth in children with non-CF bronchiectasis. METHODS The case notes of(More)