Adam Finn

Abiodun D. Ogunniyi2
Neil A. Williams2
Richard Malley2
Oluwadamilola H. Iwajomo2
Robert S. Heyderman2
2Abiodun D. Ogunniyi
2Neil A. Williams
2Richard Malley
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Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms. We previously reported that intranasal immunization of mice with pneumococci confers CD4+ T cell-dependent, antibody- and serotype-independent(More)
Regulatory T cells (Treg) diminish immune responses to microbial infection, which may contribute to preventing inflammation-related local tissue damage and autoimmunity but may also contribute to chronicity of infection. Nasopharyngeal carriage of pneumococcus is common in young children and can persist for long periods but it is unknown whether the(More)
  • Heinz-J Schmitt, Robert Booy, Robert Aston, Pierre Van Damme, R Fabian Schumacher, Magda Campins +7 others
  • 2007
BACKGROUND Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting in poor control of many vaccine-preventable diseases. DISCUSSION The Summit of Independent European Vaccination Experts focused on the perception of vaccines and vaccination(More)
  • Oluwadamilola H. Iwajomo, Peter Moons, Rose Nkhata, David Mzinza, Abiodun D. Ogunniyi, Neil A. Williams +2 others
  • 2015
OBJECTIVE Despite CD4(+) count restoration and viral load suppression with antiretroviral therapy (ART), HIV-infected children remain at increased risk of life-threatening infections including invasive pneumococcal disease (IPD). We therefore investigated whether persistent susceptibility to IPD following ART is associated with incomplete recovery of B-cell(More)
  • Emma C Anderson, Suzanne Marie Ingle, Peter Muir, Charles Beck, Adam Finn, John Peter Leeming +3 others
  • 2016
INTRODUCTION Paediatric respiratory tract infections (RTIs) are common reasons for primary care consultations and antibiotic prescribing. Locally relevant syndromic and microbiological surveillance information has the potential to improve the care of children with RTIs by normalising illness (parents) and reducing uncertainty (clinicians). Currently, most(More)
  • Johannes Trück, Matthew D. Snape, Florencia Tatangeli, Merryn Voysey, Ly-Mee Yu, Saul N. Faust +3 others
  • 2014
BACKGROUND In a previous UK multi-center randomized study 278 children received three doses of 7-valent (PCV-7) or 13-valent (PCV-13) pneumococcal conjugate vaccine at 2, 4 and 12 months of age. At 13 months of age, most of these children had pneumococcal serotype-specific IgG concentrations ≥ 0.35 µg/ml and opsonophagocytic assay (OPA) titers ≥ 8. (More)
  • Oluwadamilola H. Iwajomo, Adam Finn, Abiodun D. Ogunniyi, Neil A. Williams, Robert S. Heyderman
  • 2013
Pneumococcal disease is associated with a particularly high morbidity and mortality amongst adults in HIV endemic countries. Our previous findings implicating a B-cell defect in HIV-infected children from the same population led us to comprehensively characterize B-cell subsets in minimally symptomatic HIV-infected Malawian adults and investigate the(More)
has already been instituted in a number of countries including France, Germany and the USA following its recommendation by the Global Pertussis Initiative. 9 10 Currently, severe and fatal cases of per-tussis continue to occur in infants too young to have been fully immunised. Epidemiological studies suggest that this is because Bordetella pertussis(More)
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