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Cranial magnetic resonance imaging (MRI) is a sensitive diagnostic tool for the in vivo detection of morphological abnormalities in herpes simplex virus encephalitis (HSVE). We performed a long-term MRI study in a mouse model of HSVE. Cranial MRI findings were compared with the viral load within brain tissue, the presence of HSV DNA in the cerebrospinal(More)
We describe a prototype software system for investigating novel human-computer interaction techniques for 3-D geospatial data. This system, M4-Geo (Multi-Modal Mesh Manipulation of Geospatial data), aims to provide a more intuitive interface for directly manipulating 3-D surface data, such as digital terrain models (DTM). The M4-Geo system takes place(More)
In the brain tissue of 21 mice infected with herpes simplex virus type 1 (HSV-1) strain F we determined the expression of immunologic nitric oxide synthase (iNOS) as a potential mediator of neuronal injury with a semiquantitative reverse transcription polymerase chain reaction. Viral burden in brain tissue was quantitated with a dilutional polymerase chain(More)
College students are primarily concerned with the price and convenience of the food they choose to eat. Environmental impact is not a consideration in their food decisions. We present a web-based solution that simplifies meal choices and addresses the perception that home-prepared meals are inconvenient and expensive. The solution provides a web service(More)
The effect of acyclovir treatment on viral burden and the expression of immunologic nitric oxide synthase (iNOS) within brains of 42 HSV-1 F infected mice was studied by using a titration PCR assay for HSV-1 DNA and a semiquantitative RT-PCR for iNOS mRNA. iNOS mediated NO-production may possibly be involved in secondary mechanisms of brain injury following(More)
The continued advancement in computer interfaces to support 3D tasks requires a better understanding of how users will interact with 3D user interfaces in a virtual workspace. This article presents two studies that investigated the effect of visual, auditory, and haptic sensory feedback modalities presented by a virtual button in a 3D environment on task(More)
Meshes made from 3D points are used to represent many important geoscience concepts such as the surface of the Earth (topography), rock strata (horizons) and faults. When creating complex computer models, a geoscientist may need to directly affect the shape of such a surface to bring in in line with other data. We present a method that allows a geoscientist(More)
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