Adam C. Baughman

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Having previously introduced the mathematical framework of topological metabolic analysis (TMA) - a novel optimization-based technique for modeling metabolic networks of arbitrary size and complexity - we demonstrate how TMA facilitates unique methods of metabolic interrogation. With the aid of several hybridoma metabolic investigations as case-studies(More)
We introduce a novel, flexible, optimization-based mathematical framework for the modeling of arbitrarily complex metabolic networks: topological metabolic analysis (TMA). The framework is adapted from state-space approaches used by Manousiouthakis and co-workers for the representation of complex heat- and mass-exchanger networks. We offer a thorough(More)
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