Though many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression and analysis of cis-elements in gene… (More)
Increasing demand for human hematopoietic stem cells (HSCs) in clinical and research applications necessitates expansion of HSCs in vitro. Before these cells can be used they must be carefully evaluated to assess their stem cell activity. Here, we expanded cord blood CD34(+) CD133(+) cells in a defined medium containing angiopoietin like 5 and insulin-like… (More)
Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated malignancies. Here, we show that select microenvironments can underlie resistance to antibody-based therapy. Using a humanized model of treatment refractory B cell leukemia, we find that infiltration of leukemia cells into the bone marrow rewires the… (More)
How tumor-infiltrating lymphocytes (TILs) that are tumor-specific but functionally tolerant persist in the antigen-expressing tumor tissue is largely unknown. We have previously developed a modified TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model where prostate cancer cells express the T-cell epitope SIYRYYGL (SIY) recognized by CD8 T cells… (More)
Citation Drake, A et al. " Dendritic Cell Nediated Inhibition of Lentiviral Infection. " Retrovirology 9.Suppl 2 (2012): P178. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters.
An understanding of the factors involved in the human adaptation of influenza A viruses is critical for various aspects of influenza preparedness, including the development of appropriate surveillance measures, preventive strategies and effective treatments. A key step in influenza human adaptation is the acquisition of mutations in the viral coat… (More)
The College's 23rd annual Spring Research Conference (SRC) was held from 8 a.m. to 2 p.m. on Saturday, March 21. The SRC gives students, both undergraduate and graduate, a chance to present the results of their research from the previous year. Each student participant had twelve minutes to present his or her research, with three minutes afterward to answer… (More)