Adam Blake Neumann

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Huntington’s Disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the polyglutamine (polyQ) region of the Huntingtin (HTT) gene. The clinical features of HD are characterized by cognitive, psychological, and motor deficits. Molecular instability, a core component in neurological disease progression, can be comprehensively(More)
A two-year longitudinal study composed of morphometric MRI measures and cognitive behavioral evaluation was performed on a transgenic Huntington’s disease (HD) monkey. rHD1, a transgenic HD monkey expressing exon 1 of the human gene encoding huntingtin (HTT) with 29 CAG repeats regulated by a human polyubiquitin C promoter was used together with four(More)
Online Analytical Processing (OLAP) is an important aspect of business intelligence, where queries on multidimensional data cubes are evaluated to support decision making. Due to large data cube size, current implementations require slow and expensive offline calculations to facilitate fast online querying. As a result, user queries are evaluated on static,(More)
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