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An insulator is a DNA sequence that can act as a barrier to the influences of neighboring cis-acting elements, preventing gene activation, for example, when located between an enhancer and a promoter. We have identified a 42 bp fragment of the chicken beta-globin insulator that is both necessary and sufficient for enhancer blocking activity in human cells.(More)
Children and teens have valuable insights to offer in the design of sociotechnical learning tools and environments. Prior work has identified a range of participatory design (PD) techniques that have been used successfully to engage youth of various ages in the design process. Less understood is how youth experience and learn from their engagement in(More)
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