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Necessary and sufficient conditions are obtained for the Lipschitzian stability of local solutions to finite-dimensional parameterized optimization problems in a very general setting. Properties of prox-regularity of the essential objective function and positive defi-niteness of its coderivative Hessian are the key to these results. A previous(More)
Four cases are reported in which substantial depression was associated with the use of the calcium channel blocker nifedipine. In one instance, a patient became unresponsive to treatment with nortriptyline when nifedipine was introduced. In each case, the depression resolved following discontinuation of nifedipine. Possible mechanisms by which nifedipine(More)
Subgradient mappings have many roles in variational analysis, such as the formulation of optimality conditions and, in the special case of normal cone mappings, the statement and analysis of variational inequalities and related expressions. Central to the study of perturbations of solutions to systems of conditions in which subgradient mappings appear are(More)
Several recent investigations have suggested that neurobiological similarities may exist between patients with eating disorders and those with depression. We performed polysomnograms for two consecutive nights on nine bulimic and six anorectic patients who had no concomitant diagnosis of endogenous depression. The rapid eye movement (REM) latency, REM(More)
Pit-1, a member of the POU family of homeo-domain transcription factors, activates prolactin and GH gene expression but also has a role in pituitary cell differentiation and proliferation. Expression of Pit-1 may therefore be of central importance in the function and phenotype of human pituitary adenomas. We have found evidence that, in addition to Pit-1(More)