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The main aim of the ACuteTox project, under EU 6th Framework programme, is to investigate whether animal toxicity tests for acute systemic toxicity could be replaced by a combination of alternative assays. Data for 97 reference chemicals was collected in the ACuteTox database (Acutoxbase), designed to handle invitro and invivo (human and animal) lodged… (More)
Mutagenicity of ethylene oxide in Escherichia coli B strains with different repair capacities was studied. Deficiencies in excision repair (uvrA, polA) led to a considerable increase in mutation frequency compared with that in the wild-type strain and in strains deficient in error-prone repair (recA, lexA).
Ethylene oxide (EtO), propylene oxide (PO) and epichlorohydrin (ECH) are important industrial chemicals widely used as intermediates for various synthetic products. EtO and PO are also environmental pollutants. In this review we summarize data published during the period 1990-2001 concerning both the genotoxic and carcinogenic effects of these epoxides in… (More)
The radioprotective effect of an extract of Spirulina platensis has been studied using the micronucleus test in polychromatic erythrocytes of bone marrow of mice. In this system the extract caused a significant reduction of the micronucleus frequencies induced by gamma-radiation.
Ethylene oxide (EtO), propylene oxide (PO), and epichlorohydrin (ECH) strongly influenced the G1/S progression in human diploid fibroblasts, VH-10. However, these epoxides did not affect substantially the G2/M progression. It was found that G1 arrest is induced by these epoxides 6-18 h after the treatment at doses above 5, 3, and 0.5 mMh for EtO, PO, and… (More)
Epothilones represent a novel class of anticancer drugs which inhibit the cell cycle and strongly influence cell division. The biological activity of epothilones is associated with their capacity to bind to the protein tubulin of microtubules and to disturb the dynamic equilibrium between microtubule assembling and disassembling. Consequently, in dividing… (More)
The ACuteTox project is designed to replace animal testing for acute systemic toxicity, as is widely used today for regulatory purposes, by using in vitro and in silico alternatives. In spite of the fact that earlier studies on acute systemic toxicity demonstrated a good correlation between in vitro basal cytotoxicity data (the 50% inhibitory concentration… (More)
Bristol-Myers Squibb, in collaboration with the German Research Centre for Biotechnology, is developing BMS-310705, an epothilone analog, for the potential treatment of cancer. By April 2002, phase I trials of BMS-310705 were underway.
The influence of pre-exposure to low doses of ethylene oxide (EtO) on the frequency of leu+ revertants in the E. coli strain, WU36-10, and its excision-repair-deficient mutant, WU36-10-89, after treatment with high doses of EtO, was studied. Low doses had an adaptive effect in both strains with respect to high doses of EtO which was manifested by a… (More)