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AIMS We aimed to document the drug management of patients at high cardiovascular risk in daily practice, with the special focus on lipid-lowering treatment. METHODS AND RESULTS In this prospective noninterventional study in 2387 outpatient centers throughout Germany, a total of 13,942 high-risk patients (mean age 65.7 years, 61.6% males) were treated with(More)
AIMS Disease management programs (DMP) for diabetes mellitus (DM) or coronary heart disease (CHD) address the treatment of lipid disorders. The current registry aimed to compare drug utilization, lipid lowering effects and further outcomes of outpatients at high cardiovascular risk in DMP for DM or CHD compared to patients in routine care (no-DMP). (More)
Retinoids and vitamin A derivatives have been widely used topically and systemically in the treatment of hyper- and parakeratotic skin diseases, genodermatoses, severe acne, autoimmune diseases (i. e. lupus erythematosus) or cutaneous T-cell lymphoma for more than 30 years. In addition to the desired proliferation-inhibiting, differentiation-inducing and(More)
Hypertriglyceridaemia occurring in patients with liver disease has been studied by measuring hepatic triglyceride lipase (H-TGL) and plasma lipoprotein lipase (LPL) by selective precipitation of H-TGL with specific antibodies. Lipid analysis, determination of lecithin-cholesterol-acyltransferase (LCAT) activity, and liver function tests were performed in(More)
Patients with increased cardiovascular risk profile are frequently seen in general practice. Comprehensive management of modifiable risk factors, in particular dyslipidemia, is mandatory. Many studies in clinical practice have shown a gap between the recommendations in clinical guidelines and the actual situation. Current data on the management situation of(More)
BACKGROUND Current studies on secondary prevention of cardiovascular events (CARE, LIPID, 4S) illustrate the necessity of an effective lipid-lowering therapy. An important part of secondary prevention is the prompt measurement of lipids following an infarct, to be able to start therapy as quickly as possible. AIMS This study should show the general(More)
  • Achim Weizel
  • 2006
An unfavourable constellation of plasma lipids, e.g., a high triglyceride concentration in combination with a low HDL cholesterol concentration, is a relevant risk factor for the development of arteriosclerosis and coronary heart disease. Plasma lipids may be favourably influenced by bulk producers, in particular by plantago seed (psyllii semen). Several(More)
A multifactorial model for demonstrating the pathogenesis of the diet-induced atheromatosis of the rabbit is described. We examined the effect of various diets (atherogenetic, rich in fibre, mixed, normal) and of extreme restriction of movement, with and without doses of acetylsalicylic acid. The aorta showed uniforms morphological findings; 1.(More)