Achim J Schäffauer

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BACKGROUND Aldehyde dehydrogenase-1 (ALDH1) is involved in the regulation of cell proliferation and differentiation. Moreover, it is a marker for cancer stem cells (CSC). As CSCs were shown to be the driving force of tumor progression and metastases we suspected that the expression of ALDH1 correlated with the prognostic 5 year survival of colorectal(More)
The majority of colorectal cancers (CRCs) are characterized by a dysregulated canonical Wnt-signaling pathway leading to the stabilization and subsequent cellular increase and accumulation of β-catenin. After translocation into the nucleus, it acts as a transcription factor resulting in the expression of β-catenin target genes. These resemble most of the(More)
Durch Einsatz prädiktiver Biomarker lassen sich Ansprechraten und Gesamtüberleben von Tumorpatienten steigern. Dies wurde eindrucksvoll für die Bestimmung von Mutationen in den KRAS- und EGFR-Protoonkogenen für den Einsatz von EGFR-zielgerichteten Therapeutika für das metastasierte kolorektale Karzinom bzw. das nichtkleinzellige Lungenkarzinom gezeigt.(More)
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