Abram Aertsen

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1. We reexamine the possibilities for analyzing and interpreting the time course of correlation in spike trains simultaneously and separably recorded from two neurons. 2. We develop procedures to quantify and properly normalize the classical joint peristimulus time scatter diagram. These allow separation of the "raw" correlation into components caused by(More)
We consider several measures for the correlation of firing activity among different neurons, based on coincidence counts obtained from simultaneously recorded spike trains. We obtain explicit formulae for the probability distributions of these measures. This allows an exact, quantitative assessment of significance levels, and thus a comparison of data(More)
Cross-correlation analysis of separable multi-unit activity is one of the most commonly used methods to investigate connectivity in neural networks. In the course of development of new analysis techniques which go beyond the study of pairs or triplets of neurons, the need arose for a simple yet versatile simulator to generate spike trains from networks of(More)
In order to investigate the spectro-temporal selectivity of single auditory neurons in the auditory midbrain of the grassfrog under different stimulus conditions a stimulus ensemble consisting of tonal and natural stimuli has been constructed. The selection of characteristics of the tonal stimuli was inspired by the general properties of vocalizations of(More)
The Spectro-Temporal Receptive Field (STRF) of an auditory neuron has been introduced experimentally on the base of the average spectro-temporal structure of the acoustic stimuli which precede the occurrence of action potentials (Aertsen et al., 1980, 1981). In the present paper the STRF is considered in the general framework of nonlinear system theory,(More)
N-acyl-L-homoserine lactone (AHL) mediated quorum sensing is a widespread communication system in gram-negative bacteria which regulates a wide range of target genes in a cell density-dependent manner. Although Escherichia coli is not capable of synthesizing AHL molecules because it lacks an AHL synthase encoding gene, it does produce a predicted AHL(More)
After their first discovery in Escherichia coli, Lon homologues were found to be widely distributed among prokaryotes to eukaryotes. The ATP-dependent Lon protease belongs to the AAA(+) (ATPases associated with a variety of cellular activities) superfamily, and is involved in both general quality control by degrading abnormal proteins and in the specific(More)
Although pressure is an important environmental parameter in microbial niches such as the deep sea and is furthermore used in food preservation to inactivate microorganisms, the fundamental understanding of its effects on bacteria remains fragmentary. Our group recently initiated differential fluorescence induction screening to search for pressure-induced(More)
During fermentation of sugars, a number of bacterial species are able to switch from mixed acid production to acetoin and 2,3-butanediol production in order to avoid lethal acidification of their environment, although the regulation of this switch is only poorly understood. In this study, we report the identification of the budAB structural operon, involved(More)