Abraham John

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There has been a spectacular rise in the global prevalence of type 2 diabetes mellitus and cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. The objective of the study was to investigate ventricular myocyte shortening, intracellular Ca2+ signalling and expression of genes encoding cardiac muscle proteins in(More)
Characteristic biochemical changes have been documented in patients presenting with the symptoms and signs of gastric outlet obstruction. These changes usually consist of hypochloremic, hy-pokalemic metabolic alkalosis and hypocalcaemia with or without renal failure. The aim of this report is to highlight these biochemical abnormalities again. Moreover, we(More)
Fibrogenic growth factors can force epithelial cells of the lung, kidney and liver to undergo transition to a mesenchymal phenotype – a process known as epithelial to mesenchymal transition (EMT) 1. EMT contributes to fibrosis in these organs, and can be inhibited/reversed in animal models 2. EMT has not been shown in fibrotic skin disorders. We(More)
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