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Precise detection of L. monocytogenes hitting its highly conserved region possessing several specific antibody binding sites.
Listeria monocytogenes, a facultative intracellular fast-growing Gram-positive food-borne pathogen, can infect immunocompromised individuals leading to meningitis, meningoencephalitis andExpand
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An in silico DNA vaccine against Listeria monocytogenes.
Listeria monocytogenes causes listeriosis with mortality rate >20%. Listeriolysin-O (LLO), a pore-forming hemolysin, belongs to the family of cholesterol-dependent toxins (CDTX) and plays roles inExpand
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A potential in silico antibody-antigen based diagnostic test for precise identification of Acinetobacter baumannii.
Acinetobacter baumannii is a problematic nosocomial pathogen. The resistance to a wide range of antimicrobial agents, attributable to its biofilm phenotype, makes the treatment very difficult.Expand
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Structural pierce into molecular mechanism underlying Clostridium perfringens Epsilon toxin function
ABSTRACT Epsilon toxin of the Clostridium perfringens garnered a lot of attention due to its potential for toxicity in humans, extreme potency for cytotoxicity in mice and lack of any approvedExpand
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Conserved OprF as a Selective Immunogen against Pseudomonas aeruginosa
Background & Objectives: Due to the importance of Pseudomonas aeruginosa in severe inpatient infections and high mortality, the need for an efficient vaccine against these bacteria is increasing. InExpand
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Computational vaccinology and epitope vaccine design by immunoinformatics.
Human immune system includes variety of different cells and molecules correlating with other body systems. These instances complicate the analysis of the system; particularly in postgenomic era byExpand
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Immune response variations to Salmonella enterica serovar Typhi recombinant porin proteins in mice.
OBJECTIVES Typhoid fever is caused by Salmonella enterica serovar Typhi. OmpC, OmpF and OmpA, the three major outer membrane proteins (OMPs), could serve as vaccine candidates. METHODS The porinsExpand
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  • Open Access
In Silico Determination and Validation of Baumannii Acinetobactin Utilization A Structure and Ligand Binding Site
Acinetobacter baumannii is a deadly nosocomial pathogen. Iron is an essential element for the pathogen. Under iron-restricted conditions, the bacterium expresses iron-regulated outer membraneExpand
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  • Open Access
In silico design of an immunogen against Acinetobacter baumannii based on a novel model for native structure of Outer membrane protein A.
Outer membrane protein A (OmpA) is the most promising vaccine candidate against one of the most successful nosocomial pathogens, A. baumannii. Despite advantages of the antigen, its cytotoxicityExpand
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In silico analyses of Wilms׳ tumor protein to designing a novel multi-epitope DNA vaccine against cancer.
Predefined and pre-weighted objective criteria and essential role of Wilms׳ tumor wild type gene (WT1) for maintaining transformed features of cancer cells confirm the high potency of WT1 as aExpand
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