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BACKGROUND Breast cancer is one of the main causes of mortality and morbidity world-wide. The estimation of the direct medical costs of breast cancer can help payers of the cost to understand the burden of breast cancer on their limited financial resources as well as the society. METHODS We used a cross-sectional study to calculate the direct medical(More)
BACKGROUND The main purpose of this study is to design, formulate and evaluate the green tea gums with a suitable taste and quality in order to produce an anti-oxidant chewing gum. MATERIALS AND METHODS Fresh green tea leaves obtained from Northern Iran for extraction. Maceration is the extraction method that is used in this study. The contents of(More)
BACKGROUND The prevalence of denture stomatitis has been shown to vary from 15 to 65% in complete denture wearers. Satureja hortensis L. has been considered to have antinociceptive, anti-inflammatory, antifungal and antimicrobial activities in vitro and exhibits strong inhibitory effect on the growth of periodontal bacteria. The aim of this study was to(More)
BACKGROUND Natural products are proved to play a good role as an alternative to synthetic chemicals in clinical conditions. Previous studies showed that Pelargonium graveolens has anti-inflammatory and antifungal activity against Candida albicans. The aim of this study was to evaluate the efficacy of essential oil of Pelargonium graveolens in the treatment(More)
BACKGROUND Diabetes is associated with endothelial dysfunction and impaired wound healing. The amino acid L-arginine is the only substrate for nitric oxide (NO) synthesis. The purpose of this study was to compare the topical versus systemic L-arginine treatment on total nitrite (NOx) and vascular endothelial growth factor (VEGF) concentrations in wound(More)
Although the literature contains evidence demonstrating the beneficial effects of insulin on wound healing, no suitable method for the routine administration of insulin has been reported. A randomized, double-blind, placebo-controlled trial was conducted to determine the safety and efficacy of topical insulin on healing in 45 patients (29 men, mean age for(More)
PURPOSE The aim of this study was to design, formulate and physicochemically evaluate effervescent ranitidine hydrochloride (HCl) tablets since they are easily administered while the elderly and children sometimes have difficulties in swallowing oral dosage forms. METHODS Effervescent ranitidine HCl tablets were prepared in a dosage of 300 mg by fusion(More)
PURPOSE The aim of this study was to design and formulation of potassium citrate effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones. METHODS In this study, 13 formulations were prepared from potassium citrate and effervescent base in different concentration. The flowability of powders and(More)
BACKGROUND Periodontitis is inflammation of the supporting tissues of the teeth caused by specific microorganisms. Intra-periodontal pocket, mucoadhesive drug delivery systems have been shown to be clinically effective in the treatment of periodontitis. The aim of this study was to formulate a mucoadhesive gel from the seed hull of Quercus brantii and(More)
BACKGROUND Caffeine which exists in drinks such as coffee as well as in drug dosage forms in the global market is among the materials that increase alertness and decrease fatigue. Compared to other forms of caffeine, caffeine gum can create faster and more prominent effects. In this study, the main goal is to design a new formulation of caffeine gum with(More)