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BACKGROUND In observational studies, higher uric acid levels are associated with metabolic syndrome, diabetes, and kidney disease. OBJECTIVE The objective of this study is to examine whether reduction of plasma uric acid with febuxostat, a xanthine oxido reductase inhibitor, impacts adipose tissue oxidative stress, adipokines, and markers of systemic(More)
This paper addresses the problem of interconnect pipelining from both power consumption and bit error rate (BER) point of view and tries to find the optimal solution for a given wire pipelining scheme in nanometer scale very large scale integration technologies. In this paper a detailed analysis for the dependency of power consumption and BER on the number(More)
Hepatocyte growth factor (HGF) is a multifunctional cytokine that plays a crucial role in renal development, injury, and repair. HGF also serves a protective role in chronic renal disease by preventing tissue fibrosis. Endothelin-1 (ET-1), produced primarily by endothelial cells, is a potent vasoconstrictor that also acts as a proinflammatory peptide,(More)
With the continuous increase of circuit density, interconnect length, and aspect ratio, the influence of capacitive and inductive coupling on timing characteristics of integrated circuits has become very critical. In this paper, the effects of capacitive and inductive coupling on delay uncertainty and clock skew have been analyzed. Analytical observations(More)
In nanometer scale integrated circuits, concurrent insertion of repeaters and sequential elements into the global interconnect lines has been proposed to support multicycle communication—a concept known as interconnect pipelining. The design targets of an interconnect-pipelining scheme are to ensure high reliability, low-power consumption, and less delay(More)