Abimael D Rodríguez

Publications181
h-index31
Citations3,646
Highly Influential Citations76
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Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and…
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of… Expand
Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting…
TLDR
The preclinical pharmacology of structurally characterized marine compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner and will contribute to several pharmacological classes upon further completion of mechanism of action studies. Expand
Eupalmerin acetate, a novel anticancer agent from Caribbean gorgonian octocorals, induces apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway
TLDR
Results indicate that EPA is therapeutically effective against malignant glioma cells in vitro and in vivo and that it, or a similar marine-based compound, may hold promise as a clinical anticancer agent. Expand
Monamphilectine A, a potent antimalarial β-lactam from marine sponge Hymeniacidon sp: isolation, structure, semisynthesis, and bioactivity.
TLDR
The one-step semisynthesis of monamphilectine A was based on a multicomponent Ugi reaction that also established its absolute stereostructure and was confirmed unequivocally by chemical interconversion and comparison of physical, chemical, and bioactivity data with the natural product. Expand
Diterpenoids from caribbean gorgonians act as noncompetitive inhibitors of the nicotinic acetylcholine receptor
TLDR
Three cyclic diterpenoids isolated from gorgonians of the Eunicea genus were found to be pharmacologically active on the nicotinic acetylcholine receptor (AChR) and acted as noncompetitive inhibitors of peripheral AChR. Expand
Novel ring B abeo-sterols as growth inhibitors of Mycobacterium tuberculosis isolated from a Caribbean Sea sponge, Svenzea zeai
Abstract Assay-guided fractionation of a moderately strong anti-tubercular extract obtained from the Caribbean Sea sponge Svenzea zeai afforded two novel 5(6 → 7)abeo-sterols, named parguesterols A (… Expand
Neopetrosiamine A, biologically active bis-piperidine alkaloid from the Caribbean sea sponge Neopetrosia proxima.
TLDR
The new alkaloid displayed strong in vitro cytotoxic activity against a panel of cancer cell lines as well as in vitro inhibitory activity against the pathogenic microbes Mycobacterium tuberculosis and Plasmodium falciparum. Expand
New Marine Cembrane Diterpenoids Isolated from the Caribbean Gorgonian Eunicea mammosa
TLDR
Six new cembrane derivatives of α-methylene-δ-lactone derivatives were isolated from the lipid extract of the Caribbean gorgonian Eumicea mammosa, and the structures of these were determined by means of spectroscopic analyses. Expand
Plakortides M and N, bioactive polyketide endoperoxides from the Caribbean marine sponge Plakortis halichondrioides.
TLDR
From a small specimen of the marine sponge Plakortis halichondrioides collected in Puerto Rico, the known unsaturated ester methyl is isolated along with the known cyclic peroxide plakortide F (2) and the structures of two new polyketide endoperoxides exhibited potent cytotoxicity in the NCI human cancer screening program. Expand
The natural products chemistry of West Indian gorgonian octocorals
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