Abhishek Srivastava

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—Selecting the optimal service from a set of functionally equivalent services is non-trivial. Previous research has addressed this issue making use of Quality of Service (QoS) attributes of the candidate services. In doing this, researchers have however assumed that the customers' preference of the various QoS attributes varies linearly with the actual(More)
—Service composition is an effective practice to perform complex tasks through varied configurations of simple services. An issue that often arises in such a setup is the selection of the best service from a group of functionally equivalent ones to cater to each of the various functionalities of the composite application. Previous effort in this direction(More)
Actinobacteria within the acI lineage are often numerically dominating in freshwater ecosystems, where they can account for >50% of total bacteria in the surface water. However, they remain uncultured to date. We thus set out to use single-cell genomics to gain insights into their genetic make-up, with the aim of learning about their physiology and(More)
Selecting an optimal service from a group of functionally equivalent ones is non-trivial. This is more so when the service to be selected is part of a composite application. Research in the past has resolved this issue making use of the Quality of Service (QoS) attributes of the services to determine the most optimal from the functionally equivalents. This(More)
A program was undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a dehydrogenase of the mitochondrial electron transport chain of the malaria parasite Plasmodium falciparum. PfNDH2 has only one known inhibitor, hydroxy-2-dodecyl-4-(1H)-quinolone (HDQ), and this was used along with a range of chemoinformatics methods in the(More)
Pseudomonas syringae pv. glycinea PG4180 is an opportunistic plant pathogen which causes bacterial blight of soybean plants. It produces the exopolysaccharide levan by the enzyme levansucrase. Levansucrase has three gene copies in PG4180, two of which, lscB and lscC, are expressed while the third, lscA, is cryptic. Previously, nucleotide sequence alignments(More)
Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of CK-2-68, a molecule suitable for further development. In order to reduce ClogP and improve solubility of CK-2-68 incorporation of(More)
OBJECTIVES To evaluate (1) the prevalence of operationally defined depressive disorder (ICD-10) in chronic stroke subjects and (2) the relationship of post-stroke depression (PSD) with disability. DESIGN Cross-sectional, descriptive study. SETTING Neurological rehabilitation unit of a tertiary care university research center. MATERIALS AND METHODS(More)