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Homology modeling and molecular dynamics simulation of N-myristoyltransferase from Plasmodium falciparum: an insight into novel antimalarial drug design
TLDR
The generated structure was modeled using Modeler 9.0 taking Plasmodium vivax NMT (PvNMT) as the template and validated using various programs such as PROCHECK, RAMPAGE server, CHIMERA and the stability of the model was checked by Gromacs 5.0. Expand
ANTIMICROBIAL EFFICACY OF ORCHID EXTRACTS AS POTENTIAL INHIBITORS OF ANTIBIOTIC RESISTANT STRAINS OF ESCHERICHIA COLI
TLDR
All the three orchid species has good antimicrobial activity against the three strains of E. coli, opening a new area for antimicrobial drug design research. Expand
High throughput screening of 7-methylpicene-1,2-diol as arylamine N-acetyltransferase (NAT) inhibitor to establish a isoniazid supplement in anti-tubercular therapy.
TLDR
Computational drug design has been performed in this work to find potent NAT inhibitor to raise the efficacy of isoniazid and validated 7- methylpicene-1, 2-diol to be a potent NAT inhibitors to supplement isoniaZid. Expand
An in silico appraisal of azoic and disulphide derivatives for anticancer activity against HPV E6 oncoprotein to medicate cervical cancer.
TLDR
A blueprint of compounds with desirable properties that may lead to the development of drugs to treat HPV-associated neoplasias are proposed and found more effective than those of the approved E6-E6AP binding inhibitors. Expand
Virtual high throughput screening of carbapenem derivatives as new generation carbapenemase and penicillin binding protein inhibitors: a hunt to save drug of last resort.
TLDR
In this work, over thousands of thienamycin (first natural carbapenem) derivatives were generated and out of which non-toxic 273 molecules were used for further study, only few followed the first hypothesis and rest obeyed the second. Expand
Acute dorsal myelopathy resulting from intramedullary cysticercus: a case report
TLDR
Rare manifestation of a rare but treatable disorder makes it an important reportable observation in the context of tropical medicine. Expand
A case of complicated bullous systemic lupus erythematosus managed with Rituximab
TLDR
A 21-year-old female presented with fever, polyarthalgia and vesicobullous skin lesion and acute renal failure with bullous systemic lupus erythematosus with l upus nephritis and responded dramatically with resolution of skin lesions and recovery from acute renal Failure. Expand
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