Abhinendra Kumar

Learn More
Free radicals and other reactive oxygen species (ROS) have been implicated as playing an important role in tissue damage in a variety of pathological processes (Nohl et al., 1996). Overproduction of ROS in diverse pathological conditions leads to oxidative damage to macromolecules, resulting in enhanced lipid peroxidation, DNA strand breaks and protein(More)
Bacterial lipoproteins are emerging targets for inducing protective immunity against many infectious diseases. VacJ is a highly conserved and widely distributed outer membrane lipoprotein of Pasteurella multocida strains, which are known to affect a wide range of domestic as well as wild animals and birds. In the present study, the gene encoding for mature(More)
Pasteurella multocida serogroup B:2, a causative agent of haemorrhagic septicaemia (HS) in cattle and buffalo especially in tropical regions of Asian and African countries, is known to possess several outer membrane proteins (OMPs) as immunogenic antigens. In the present study, omp87 gene encoding for 87 kDa OMP (Omp87) protein of P. multocida serogroup B:2(More)
Transferrin binding protein A (TbpA), an iron acquisition surface protein that also acts as virulence factor, is widely distributed among strains of Pasteurella multocida. In the present study, a total of seven clones of TbpA fragments (39D to F777; 39D to Q697; 188V to F777; 188V to Q697; 39D to P377; 188V to P377 and 39D to F187) belonging to P. multocida(More)
Outer membrane lipoproteins are widely distributed in Gram-negative bacteria which are involved in diverse mechanisms of physiology/pathogenesis. Various pathogenic bacterial strains belonging to the family-Pasteurellaceae have several surface exposed virulence factors including VacJ/VacJ-like lipoproteins. In the present study, vacJ gene encoding for VacJ(More)
Pasteurella multocida, a Gram-negative bacterial pathogen, known to affect a wide range of domestic as well as wild animal and avian species throughout the world by causing either systemic or localized infections termed as ‘pasteurellosis’. P. multocida isolates are known to possess type IV fimbriae (pili) as one of the major virulence factors based on(More)
BACKGROUND Cancer is a fatal disease and is on the rise across the globe. In India, breast, cervix and the oral cavity are the leading cancer sites, but, unfortunately, in-spite of availability of screening tools, there is no organized cancer screening program in India. The main objective of this study was to review the performance of various cancer(More)
Bacterial lipoproteins of varying size and functional role in physiology/pathogenesis are widely prevalent among Gram-negative bacterial species. Among virulent bacteria, Pasteurella multocida is known to be associated with diverse infectious diseases of livestock worldwide and possess several outer membrane proteins (OMPs) as virulence factors. In the(More)
Emaciation and general weakness are common clinical signs in many chronic diseases, probably owing to interplay between anorexia, increased energy demands of an ailing animal and the changing endocrine environment (Ziegler et al., 1994). The adrenal glands, the thyroid, and the pancreas are of prime importance in energy metabolism and in the adaptation of(More)
  • 1