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Globally only 5-10% of people encountering Mycobacterium tuberculosis have a lifetime risk of active disease indicating a strong host genetic bias towards development of tuberculosis. In the current study we investigated genotype variants pertaining to five cytokine genes namely IFNG, TNFA, IL4, IL10 and IL12 in the north Indian population with active(More)
Ethnic specificity is a key determinant in understanding the association of genetic variants with outcome of disease susceptibility. SP110, a component of the nuclear body, has been subjected to association studies with conflicting results. In this study we probed SP110 variants in pulmonary (PTB) and lymph node tuberculosis (LNTB) cases to explore their(More)
AIM We examined whether HLA-DRB1*1501 and four VDR SNPs influence the macrophage response to infection with Mycobacterium tuberculosis (Mtb) via innate immune versus drug treatment or drug delivery mechanisms. MATERIALS & METHODS Monocyte-derived macrophages from 24 healthy donors were infected with Mtb in vitro. Survival of intracellular bacilli and(More)
BACKGROUND & OBJECTIVES Tuberculosis is (TB) responsible for high morbidity and mortality worldwide. Cytokines play a major role in defense against Mycobacterium tuberculosis infection. Polymorphisms in the genes encoding the various pro- and anti-inflammatory cytokines have been associated with tuberculosis susceptibility. In this study we examined(More)
Emerging evidence indicates that the causative agent of tuberculosis is more genetically and functionally diverse than appreciated previously. The impact of this variation on the clinical manifestation of the disease remains largely unknown. In addition, there exists significant variability in the immune status of the host governing susceptibility to(More)
BACKGROUND Tubercular lymphadenitis (TL) is the most common form of extra-pulmonary tuberculosis (TB) consisting about 15-20% of all TB cases. The currently available diagnostic modalities for (TL), are invasive and involve a high index of suspicion, having limited accuracy. We hypothesized that TL would have a distinct cytokine signature that would(More)
We were pleased to read the article entitled “The IL-17F sequence variant is associated with susceptibility to tuberculosis” in your reputed journal (Peng et al., 2013). The authors in order to address the role of IL17 gene polymorphisms in tuberculosis show that a variant in IL17F gene is associated with tuberculosis. The study uses a good sample size and(More)
According to the World Health Organisation South Africa has the third highest tuberculosis (TB) incidence in the world, with an estimated 60 % incident cases having both TB and HIV. The South African National Tuberculosis Association (SANTA) recognized the importance of nutrition in the prevention and management of TB by including feeding schemes in(More)
. Abstract Carrier to Noise Ratio (CNR) has been investigated for radio over fiber systems including the effects of variation in the RF oscillator linewidth in this paper. Optical Single sideband signal is studied as it has tolerance for power degradation due to dispersion effects over a length of fiber. Investigations have been made out for Radio frequency(More)
Congratulations to Dr. Birbian and colleagues for their article ‘‘GSTT1 and GSTM1 Gene Polymorphisms as Major Risk Factors for Asthma in a North Indian Population’’ [1]. Theirs was the first published study on GSTT1 and GSTM1 genetic polymorphisms in a north Indian population using a case–control design. The study was carried out on a good sample size and a(More)