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The aversive properties of naloxone-precipitated withdrawal from acutely administered morphine were assessed using the place-conditioning paradigm. The conditioned place aversion produced by naloxone (0.5-1.0 mg/kg, s.c.) after two conditioning trials was enhanced by pretreatment with morphine (20 mg/kg, s.c.) 24 h prior to the conditioning trial. Naloxone(More)
We investigated the ability of dopamine D1 and D2 class receptor antagonists to prevent the induction of behavioral sensitization to cocaine. The D2 receptor antagonist eticlopride failed to prevent the induction of cocaine sensitization. An intermediate dose of the D1 receptor antagonist SCH 23390 (0.1 mg/kg) appeared to prevent the induction of cocaine(More)
– A distributed sensing/fusion network consists of more than one (spatially) separated sensors, each with possibly different characteristics and not all of them sensing the same environment. Due to their vast applicability, there has been a flurry of recent activity in the area of network design with respect to distributed sensing/fusion. Issues involved in(More)
Software Asset re-use has the potential to enhance the quality and reduce the time to market of software projects. However, there are many challenges on the road to successful asset re-use. The key to success is discipline. This paper proposes a model for effectively managing the software assets re-use program. It also addresses the challenge of sustaining(More)
PURPOSE The purpose of these investigations was to develop an improved method for measuring precorneal residence time (RT) and to demonstrate its efficacy with novel formulations. METHODS A biomicroscope was adapted for use as a clinical fluorometer. Using a nonpenetrating fluorescent probe (FITC-dextran, 70,000-73,000 molecular weight [MW]), RT was(More)
A dependable in vitro in vivo correlation (IVIVC) is a vital tool to optimize drug formulation and expedite product development time. Although many IVIVC examples are available for oral delivery systems, IVIVC for transdermal delivery is far less common, especially for electrical-assisted delivery. The objective of this study was to develop an IVIVC for the(More)
A Brief Review on Rational Consideration of Fixed Dose Combinations. ABSTRACT The irrational prescription of fixed dose combinations is a major health concern in our country. The Indian pharmaceutical market is flooded with fixed dose combinations. The production and sale of these products are increasing day by day. Few of such products have ethical and(More)
Psoralea corylifolia Linn were used traditionally in Ayurveda for the treatment of male sexual dysfunction. The extract was administered (100 and 200 mg/kg, p.o.) to different groups of male rats. The female rats involved in mating were made receptive by hormonal treatment. The orientational activity, body weight, haematoogical parameters were studied and(More)