Abeer Essam El-Din Mahmoud

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New series of pyrazolo[3,4-d]pyrimidines (7a-e and 13a-d) and pyrazole hydrazones 17a-d were synthesized and evaluated for their antiproliferative activity against human breast adenocarcinoma MCF-7 cell line. Most of the tested compounds exploited potent to moderate growth inhibitory activity, in particular compound 7e exhibited superior potency to the(More)
A series of novel substituted pyrazolo[3,4-d]pyrimidines (compounds 2-12) were synthesized starting with pyrimidinone derivative 1. Their in vitro cytotoxicity against human breast adenocarcinoma (MCF-7) cell lines has been investigated and most of the tested compounds exploited potent cytotoxic activity against MCF-7 cell lines comparable to the activity(More)
Natural products are economically beneficial, safe and had promising effect. The natural sources such as plants, fruits and vegetables are rich in bioactive compounds which are valuable products for pharmaceutical industry. In fruit processing industry, large volumes of its residual were dumped and thrown as waste material which will be useful if it can be(More)
A novel series of 5-nitro-1H-benzimidazole derivatives substituted at position 1 by heterocyclic rings was synthesized. Cytotoxicity and antiviral activity of the new compounds were tested. Compound 3 was more active than doxorubicin against A-549, HCT-116 and MCF-7. However, compound 3 showed no activity against human liver carcinoma Hep G-2 cell line.(More)
Utilization of three food processing wastes (lemon pulp, papaya fruit waste and rice straw) for the production of fruit bodies mushroom with edible fungi Pleurotus ostreatus NRRL-0366 was done using solid state fermentation technique. Rice straw supplemented with different concentrations of the other two wastes forming eight substrates was used in this(More)
This study was conducted to determine the total poly phenols and flavonoids, estimation of antioxidant activity in vitro by two methods (DPPH radica -carotene) for 16 plant leaves. Radish ( white, red ) , attract, cabbage ( white, red ), dill, boil, carrots (red, yellow), red beet, sugar beet, cauliflower, coriander, parsley, spinach and lettuce extracted(More)
A series of novel substituted pyrimidinones and fused pyrimidinones (compounds 3-18) were synthesized starting with oxiranylmethanone 2. The in vitro cytotoxicity against a human breast adenocarcinoma (MCF-7) cell line was investigated and most of the tested compounds showed potent cytotoxic activity against the MCF-7 cell line comparable to the activity of(More)
The design, synthesis, and in vitro antiproliferative activity of a novel series of sulfide (4a-i) and sulfoxide (5a-h) derivatives of benzimidazole, in which different aromatic and heteroaromatic acetamides are linked to benzimidazole via sulfide (4a-i) and sulfoxide (5a-h) linker, are reported and the structure-activity relationship is discussed. The new(More)
Tannase is considered one of the most important industrial enzymes that find great applications in various sectors. Production of tannases through solid state fermentation (SSF) using agro-industrial wastes is an eco-friendly and cheap technology. Tannase was produced by the yeast Kluyveromyces marxianus using olive pomace as a solid support under SSF. It(More)
2-Chloroquinoline-3-carbaldehyde (1) was condensed with the acetyl reagents 2a−e under the Claisen-Schmidt reaction conditions. In general, two products were formed, separated by column chromatography and proved by the spectroscopic data to be the two possible conformers E-s-cis-3a-c and E-s-trans-3a-c of the respective chalcones. However, reaction of 1(More)