Abdullah Shah

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An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly(More)
This article presents a time-accurate numerical method using high-order accurate compact finite difference scheme for the incompressible Navier–Stokes equations. The method relies on the artificial compressibility formulation, which endows the governing equations a hyperbolic–parabolic nature. The convective terms are discretized with a third-order upwind(More)
This paper presents a new version of the upwind compact finite difference scheme for solving the incompressible Navier-Stokes equations in generalized curvilinear coordinates. The artificial compressibility approach is used, which transforms the elliptic-parabolic equations into the hyperbolic-parabolic ones so that flux difference splitting can be applied.(More)
p53, known as a tumor suppressor, is a DNA binding protein that regulates cell cycle, activates DNA repair proteins, and triggers apoptosis in multicellular animals. More than 50% of human cancers contain a mutation or deletion of the p53 gene, and p53R175 is one of the hot spots of p53 mutation. Nucleic acid aptamers are short single-stranded(More)
Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests(More)
A new version of numerical solver for simulating two-phase incompressible viscous flows is developed in the present study. The governing equations consists of the Navier-Stokes equations with Boussinesq approximation and surface tension terms acting at the interface coupled with the phase field equation representing the moving interface. The system of(More)
MicroRNAs (miRNAs) play important roles under multiple cellular conditions including endoplasmic reticulum (ER) stress. We found that miR-3648, a human specific microRNA, was induced under ER stress. Moreover, Adenomatous polyposis coli 2 (APC2), a tumor suppressor and a negative regulator of Wnt signaling, was found to be the direct target of miR-3648.(More)
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