Abdullah M. M. Faqehi

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CONTEXT Deficiency of aromatase, the enzyme that catalyzes the conversion of androgens to estrogens, is associated with insulin resistance in humans and mice. OBJECTIVE We hypothesized that pharmacological aromatase inhibition results in peripheral insulin resistance in humans. DESIGN This was a double-blind, randomized, controlled, crossover study. (More)
Benign prostatic hyperplasia and prostate cancer can be treated with the 5α-reductase inhibitors, finasteride and dutasteride, when pharmacodynamic biomarkers are useful in assessing response. A novel method was developed to measure the substrates and products of 5α-reductases (testosterone, 5α-dihydrotestosterone (DHT), androstenedione) and finasteride and(More)
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