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Docosahexaenoic acid: one molecule diverse functions
TLDR
A robust link between DHA and cognitive health is demonstrated and a host of mechanisms have been proposed, including DHA, which inherently has a characteristic three-dimensional structure, increases membrane fluidity, strengthens antioxidant activity and enhances the expression of several proteins that act as substrates for improving memory functions. Expand
Inflammatory Responses are Sex Specific in Chronic Hypoxic–Ischemic Encephalopathy
TLDR
It is concluded that a sex dichotomy in pro- and anti-inflammatory response underlies the sex-specific chronic HIE outcomes, and an enhanced neurogenesis in females also contribute to the sex difference. Expand
APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis
TLDR
ApoE has great influence in tau pathogenesis, tau-mediated neurodegeneration, and neuroinflammation, as well as α-synucleinopathy, lipid metabolism, and synaptic plasticity despite the presence of Aβ pathology. Expand
Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology
TLDR
This review progresses existing knowledge to reveal the promising linkage of traditional medicine to halt AD pathogenesis and also avowed a new insight to search the promising anti-Alzheimer’s drugs. Expand
n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats.
TLDR
The findings of the present study suggest that long-term EPA+DHA administration may be a possible preventative strategy against age-related cognitive decline. Expand
Exploring the Multifunctional Neuroprotective Promise of Rasagiline Derivatives for Multi-Dysfunctional Alzheimer's Disease.
TLDR
It has been revealed that both the compounds possess anti-AD effects and therefore, the clinical development is directed to the treatment of this type of neurodegenerative diseases (NDs). Expand
Long Non-coding RNA Based Cancer Classification using Deep Neural Networks
TLDR
The capability of lncRNA in classifying cancer types by employing four deep neural networks - multi-layer perceptron (MLP), longshort- term memory (LSTM), convolutional neural network (CNN) and deep autoencoder (DAE) is explored. Expand
Spectrum of Disease and Prescription Pattern for Outpatients with Neurological Disorders: An Empirical Pilot Study in Bangladesh
TLDR
Examination of the prevalence and prescription pattern for outpatients with neurological disorders in Bangladesh found that neurological diseases are more prevalent than other different diseases among different age groups and genders. Expand
Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer’s Disease
TLDR
This review focuses on the role of UPS in the pathogenesis of AD and highlights how the UPS-linked treatments influence in the management of AD. Expand
Omega-3 Fatty Acids Protect Renal Functions by Increasing Docosahexaenoic Acid-Derived Metabolite Levels in SHR.Cg-Leprcp/NDmcr Rats, a Metabolic Syndrome Model
TLDR
The results show that the use of combination therapy with DHA and EPA in SHRcp rats improved or prevented renal failure associate with metabolic syndrome with decreasing triglyceride levels and increasing ω-3 PUFA lipid mediators. Expand
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