Abdul-Salam Abdul-Ghani

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The protective effect of amygdaloid (focally administered) doses of the presynaptic metabotropic glutamate receptor agonist, L-2-amino-4-phosphonobutyrate (L-AP4) was tested on the development of electrical kindling and in fully kindled animals. L-AP4 inhibited epileptogenesis at 10 nmol in 0.5 microl buffer, by preventing the increase in both seizure score(More)
The effects of intracerebral administration of the group II metabotropic glutamate receptor agonist, 2R,4R-APDC, were tested on both the development of amygdaloid kindling and on fully developed stage 5 amygdala kindled seizures. The development of amygdaloid kindling was significantly retarded in 2R,4R-APDC (10 nmol in 0.5 microl) treated animals compared(More)
beta-Bungarotoxin, a snake neurotoxin purified from the venom of Bungarus multicinctus, caused a significant increase in the in vivo release of glutamate from the superfused sensorimotor cortex of awake animals. A smaller effect on GABA release was observed, but no change was detected in the release of six other amino acids measured. The effects on(More)
The cardiovascular effects of aqueous extracts from the branches of Commiphora opobalsamum tree were investigated. The intravenous administration of 4 mg/kg of the aqueous extract depressed systemic arterial blood pressure by 20% (P < 0.01) and reduced heart rate of anaesthetised rats by 14% (P < 0.05). The hypotensive and the bradycardiac effects were(More)
Treatment of male albino rats with 5% honey for 20 days had no significant effect on total body weight or on the relative weight of other organs like the testis, seminal vesicles, spleen, kidneys, liver, heart, or brain. The only significant change was a 17% increase in the relative weight of the epididymis (P < or = .01). The relative weight of all the(More)
The effects of gamma-vinyl-GABA (4-amino-hex-5-enoic acid, RMI 71754) and gamma-acetylenic-GABA (4-amino-hex-5-ynoic acid, RMI 71645), the selective and irreversible inhibitors of GABA-transaminase (E.C. 2.6.1.19), on the resting and stimulated release of GABA and other amino acids from sensorimotor cortex of rats was studied using a superfusion technique.(More)
The effect of copper(II) complexes on glucose metabolism was studied in normal and streptozotocin-induced diabetic rats. The copper(II) complexes used were bis(acetato)tetrakis(imidazole) copper (II), [Cu(OAc)2(Im)4], bis(acetato)bis(2-methylimidazole) copper(II), [Cu(OAc)2(1,2dmIm)2], and bis)acetato)bis(μ-acetato)tetrakis(N-methylimidazole) copper(II)(More)
Perforated discs of cobalt or nickel were implanted onto the sensorimotor strip of the cerebral cortex of rats. Co discs gave rise to myoclonic contralateral limb-jerks in a manner similar to Co powder lesions. In contrast, Ni-implanted animals were never observed to show overt limb-jerks. On superfusion with an in vivo cannula system, both types of lesion(More)
The anticonvulsant activity of bis(acetato)tetrakis(imidazole) copper(II), Cu(OAc)2(Im)4, was studied in normal mice using chemical convulsions induced by strychnine, thiosemicarbazide, picrotoxin, and pentelenetetrazol. Intraperitoneal administration of Cu(OAc) 2(Im)4, 50 mg/kg body mass, has delayed the onset of strychnine (3 mg/kg)-induced convulsion by(More)