Abdul Khalique

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The distribution and pharmacokinetics of [3H]physostigmine (Phy) and the relationship between the time course of Phy concentration and butyrylcholinesterase (BuChE) inhibition in plasma was studied in rat after im administration (650 micrograms/kg). The concentrations of Phy and its metabolites were determined in plasma and brain by high-performance liquid(More)
A specific, reliable, and accurate high performance liquid chromatographic method is described for the determination of physostigmine in plasma and brain using carbaryl as an internal standard. Plasma and brain containing physostigmine were first precipitated with TCA, and then carbaryl was added. This was followed by chloroform extraction and then(More)
The uptake and metabolism of 2,4-[14C]dichlorophenol (2,4-[14C]DCP) was studied in the isolated perfused rat liver. The uptake of radioactivity in liver increased 6.6% (25.3-31.9%) in the presence of adenosine 5'-triphosphate (ATP) and 14.9% (25.3-40.2%) in the presence of ATP and galactosamine. This increase in the uptake of radioactivity was indicative of(More)
The time course of physostigmine (Phy) and metabolites in plasma, brain, and muscle, the inhibition of butyrylcholinesterase (BuChE) in plasma, and cholinesterase (ChE) activity in brain and muscle were studied in rat after iv bolus administration of 3H-Phy (100 micrograms/kg). The semilogarithmic plot of plasma Phy concentration versus time indicates a(More)
A physiological model for physostigmine disposition was developed in the rat which incorporated anatomical, physiological, and biochemical parameters, i.e. tissue volume, plasma flow rates, drug metabolism, and tissue-to-plasma partition coefficients. Predicted concentrations of physostigmine in different tissue compartments were consistent with the(More)
The metabolism and distribution of 2,4-dichlorophenol (2,4-DCP) were studied in the rat after intravenous administration of 10 mg/kg. 2,4-DCP was determined by gas chromatography with an electron-capture detector. The highest concentration of 2,4-DCP was found in kidney, followed by liver, fat, and brain. 2,4-DCP is metabolized to glucuronide and other(More)
Insulin maintains glucose homeostasis by stimulating glucose uptake from extracellular environment to adipose and muscle tissue through glucose transporter (GLUT4). Insulin resistance plays a significant role in pathologies associated with type2 diabetes. It has been previously shown that hyperinsulinemia can lead to insulin resistance. In these studies(More)