Abdul-Badi Abou-Samra

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Chromosome maintenance region 1 (CRM1) also called Exportin 1 (Xpo1), a protein found elevated in pancreatic ductal adenocarcinoma (PDAC), blocks tumor suppressor protein (TSP) function through constant nuclear export. Earlier we had shown that targeting CRM1 by our newly developed specific inhibitors of nuclear export (SINE) leads to inhibition of(More)
UNLABELLED 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been variably noted to affect hepatitis C virus (HCV) treatment response, fibrosis progression, and hepatocellular carcinoma (HCC) incidence, with some having a more potent effect than others. We sought to determine the impact of adding statins to antiviral therapy upon(More)
Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D. It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance. The objective of this study was to determine the pattern of circulating lactate(More)
BACKGROUND Changes in lipid levels over time after acquiring HCV infection, and how they differ from HCV-uninfected persons are unknown. METHODS We used ERCHIVES to identify those with a known HCV seroconversion window and persistently negative controls. We excluded subjects with HIV and hepatitis B and those who received lipid lowering agents. Total(More)
Background Risk of AMI among HCV+ versus HCV- persons with similar lipid levels is unknown. We determined incident AMI rates among HCV+ and HCV- men among various lipid strata. Methods We created a propensity score matched (PSM) cohort, and a low cardiovascular disease (CVD) risk cohort. Primary outcome was incident AMI rates by HCV status in each lipid(More)
The PTH/PTHrP receptor belongs to a novel family of G protein-coupled receptors. Its complex gene spans about 25 kb of genomic DNA, and contains fourteen coding and at least three non-coding exons. Rat and opossum PTH/PTHrP receptors share 78% amino-acid identity, and 91% of the residues are identical when comparing the rat and human receptor homologs.(More)
BACKGROUND Antibiotics are often inappropriately prescribed for upper respiratory tract infections (URTIs) in developed countries. Data on the proportion of inappropriate prescriptions are lacking from the Middle East and other developing countries. METHODS Health insurance claims for all antibiotics prescribed for URTIs in the private sector in the State(More)
  • Susumu Uneno, Takao Yamamuro, +4 authors Gino V. Segre
  • 1992
ROS17/2.8 cells, a cell line derived from a rat osteosarcoma, have abundant receptors for parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). A particulate membrane fraction was prepared from these cells and it was solubilized using relatively mild conditions with digitonin (0.25%), a nonionic detergent. When radioligands of both PTH(More)
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