Abdellatif Mohamed Salaheldin

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Enamines are versatile reagents that are currently utilized extensively as synthetic equivalents of aldehydes [1 – 5]. In earlier work we have shown that functionally substituted enamines are versatile precursors to otherwise not readily obtainable active methylene aldehydes [6 – 8]. In conjunction with this work, we report here a synthesis of the title(More)
N1-Substituted-5-amino-4-cyanopyrazoles were cyanoacetylated with a mixture of cyanoacetic acid and acetic anhydride. Cyclization with POCl3 gave 4-chloro-pyrazolo[3,4-d]pyrimidine derivatives. From the reaction with hydrazine and arylhydrazines, the hydrazinyls and their oxidized forms, the azo products, were obtained. The structure of the compounds(More)
The chemistry of azolopyrimidines has in the past received considerable interest [1 – 5] and is still an area of major interest [6, 7]. Recently azoloazines have been shown to be of antimicrobial, antioxidant [8] and agrochemical importance. Moreover they are a promising new class of dyes for D2T2 printing and hair dyes [9, 10]. Microwave heating has been(More)
Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the(More)
Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the(More)
The reaction of indole derivatives with cyanoacetic acid followed by treatment with DMFDMA gave the intermediate indolyl enaminonitriles (3). Further reaction with aminoguanidine yielded 5 ́-cyanomeridianin analogues (4). The same intermediate reacted with pmethoxyphenylhydrazine to give the pyrazolyl derivative (8). Treatment of(More)
Efficient routes to various kinds of heterocycles incorporating the p-halophenyl moiety have been synthesized. Different pyrrole derivatives have been synthesized, as well, by Thorpe-Ziegler cyclization. Therefore, we synthesized different analogues of tacrine by Friedländer reaction of o-amino nitriles (pyrazolo, furano and pyrrolo) with different(More)
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