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Extracts from the leaves of Ginkgo biloba trees have been used therapeutically for centuries in traditional Chinese medicine, and in modern Chinese pharmacopoeias both the leaves and fruits are… (More)
Publisher Summary Extracts of Ginkgo biloba leaves (EGb 761) are complex titrated, standardized mixtures of active ingredients introduced into medical practice as polyvalent therapeutic agents. This… (More)
Certains derives de l'ellipticine sont bien connus pour leurs proprietes cytotoxiques et antitumorales. L'hypothese d'une activation metabolique, in vivo, de ces substances, par voie radicalaire,… (More)
Many xenobiotics need a free-radical mediated metabolism activation to exhibit their biological properties. Among them, antitumor drugs such as anthracycline or ellipticine derivatives are known to… (More)
We studied by pulse radiolysis three aspects of the oxydoreduction of three antitumour drugs whose mechanisms of action imply one-electron oxidative or reductive activations. The three antitumour… (More)
BD40, a new antitumor drug derived from 9-azaellipticine, is thought to have an oxygen-dependent metabolism in vivo. We have investigated the one-electron oxidation of this drug by gamma radiolysis… (More)