Abdelaziz Mahoui

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This paper examines the issues surrounding distributed Digital Library protocols. First, it reviews three prominent digital library protocols: Z39.50, SDLIP, and Dienst, plus Greenstone’s own protocol. Then, we summarise the implementation in the Greenstone Digital Libary of a number of different protocols for distributed digital libraries, and describe(More)
The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can both modulate biological targets and have drug-like physicochemical properties continues to be a topic of(More)
Historically, one of the characteristic activities of the medicinal chemist has been the iterative improvement of lead compounds until a suitable therapeutic entity is achieved. Often referred to as lead optimization, this process typically takes the form of minor structural modifications to an existing lead in an attempt to ameliorate deleterious(More)
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