Abdel-Fattah El-Shershaby

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SUMMARY In the zona pellucida-intact 95 h post coitum mouse blastocyst, electron-microscopic studies reveal the presence, as a part of normal development, of 1-2 dead cells lying free on the surface of the inner cell mass (ICM) or trophoblast cells, and of 4-5 dead cells phago-cytosed by ICM cells. Such dead cells are electron-dense and show characteristic(More)
An ultrastructural investigation was made of cell death in the uterine epithelium during the implantation of the mouse blastocyst. Cell death occurs in two phases: (i) early individual cell death, and (ii) later general cell death. Individual dead epithelial cells are phagocytosed and digested by trophoblast cells. At 95 h post coitum (p.c.) there are 1-4(More)
Arachis oil instilled into the uterus of sensitized mice was localized mesometrially or, more commonly, antimesometrially, suggesting that the uterus is polarized in its capacity to respond since implantation chambers only form antimesometrially. Epithelial breakdown occurred only within the 'implantation chabmer', but cell death took place more rapidly(More)
BACKGROUND Pregnant women are more susceptible to both vaginal colonization and infection by yeast. One hundred million fungal infected patients have been treated worldwide with itraconazole (Caputo, 2003. METHOD Itraconazole was administrated orally to pregnant rats at doses of 75, 100, or 150 mg/kg during gestational days (GD) 1 to 7 or GD 8 to 14 or GD(More)
The present study aimed to investigate the teratogenic and genotoxic effects of itraconazole administered orally to pregnant rats on gestation days 1-7 (implantation), 8-14 (organogenesis) and 14-20 (fetal developmental period) at doses 75, 100 or 150 mg/kg b.wt. The results indicated that itraconazole had embryolethal effect when administered at a dose of(More)
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