Abdallah M. Abdallah

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  • Abdallah Am, Verboom T, Weerdenburg Em, Gey Van, Pittius Nc, Mahasha Pw +15 others
  • 2014
SUMMARY ESX-5 is one of the five type VII secretion systems found in mycobacteria. These secretion systems are also known as ESAT-6-like secretion systems. Here, we have determined the secretome of ESX-5 by a proteomic approach in two different strains of Mycobacterium marinum. Comparison of the secretion profile of wild-type strains and their ESX-5 mutants(More)
Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across their unusual cell envelope. One of these systems, ESX-5, is only present in slow-growing mycobacteria and responsible for the secretion of multiple substrates. However, the role of ESX-5 substrates in growth and/or virulence is largely unknown. In this study, we show(More)
ESX-5 is a mycobacterial type VII protein secretion system responsible for transport of numerous PE and PPE proteins. It is involved in the induction of host cell death and modulation of the cytokine response in vitro. In this work, we studied the effects of ESX-5 in embryonic and adult zebrafish using Mycobacterium marinum. We found that ESX-5-deficient M.(More)
UNLABELLED Conjugative plasmids have been identified in a wide variety of different bacteria, ranging from proteobacteria to firmicutes, and conjugation is one of the most efficient routes for horizontal gene transfer. The most widespread mechanism of plasmid conjugation relies on different variants of the type IV secretion pathway. Here, we describe the(More)
Although Bacillus Calmette-Guérin (BCG) vaccines against tuberculosis have been available for more than 90 years, their effectiveness has been hindered by variable protective efficacy and a lack of lasting memory responses. One factor contributing to this variability may be the diversity of the BCG strains that are used around the world, in part from(More)
The emergence and spread of multidrug-resistant (MDR) bacteria have been regarded as major challenges among health care-associated infections worldwide. Here, we report the draft genome sequence of an MDR Stenotrophomonas maltophilia strain isolated in 2014 from King Abdulla Medical City, Makkah, Saudi Arabia.
6 SUMMARY Broad-host pathogens have adapted a lifestyle that enables them to survive and replicate in different environments. Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, is such an intracellular pathogen that can infect, survive and replicate in phagocytic cells of vertebrates as well as protozoan species. Here, we employed(More)
5 SUMMARY The mycobacterial type VII secretion system ESX-1 is responsible for secretion of a number of proteins that play an important role during infection of the host. Regulation of expression of secreted proteins is often essential to establish a successful infection. Using transcriptome sequencing (RNA-seq), we found that abrogation of ESX-1 function(More)
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