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RanBP2/Nup358 Potentiates the Translation of a Subset of mRNAs Encoding Secretory Proteins
After nuclear export, mRNAs encoding secretory proteins interact with RanBP2/Nup358 on the cytoplasmic face of the nuclear pore, a step that is required for the efficient translation of these mRNAs.
Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes
TLDR
The results show strong correlation between 5′ untranslated region (5′UTR) intron presence/absence and sequence features at the beginning of the coding region, and suggest that genes encoding secretory and mitochondrial proteins share a common regulatory mechanism at the level of mRNA export. Expand
Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements.
TLDR
Evidence that β-globin mRNA contains an element that actively retains it in the nucleus and degrades it is provided, suggesting that contrary to many current models, the default pathway for most intronless RNAs is to be exported from the nucleus, unless the RNA contains elements that actively promote its nuclear retention. Expand
Trafficking of mRNAs containing ALREX-promoting elements through nuclear speckles
TLDR
The data suggest that within the speckle, ALREX-promoting elements, in conjunction with the poly(A)-tail, likely stimulate UAP56/URH49 and TAP dependent steps that lead to the eventual egress of the export-competent mRNP from these structures. Expand
Nuclear export as a key arbiter of "mRNA identity" in eukaryotes.
TLDR
How mRNA identity is assessed by the nuclear export machinery in order to extract meaningful information from the eukaryotic genome is discussed and an explanation of why certain sequences that are enriched in protein-coding genes, such as the signal sequence coding region, promote mRNA nuclear export in vertebrates is provided. Expand
The Consensus 5' Splice Site Motif Inhibits mRNA Nuclear Export
TLDR
The data suggests that the presence of the 5’splice site motif in mature RNAs promotes their nuclear retention and may help to distinguish mRNAs from misprocessed transcripts and transcriptional noise. Expand
A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification.
TLDR
All analyses point to the existence of a distinct 5IM class comprising ∼20% of human transcripts, defined by depletion of 5' proximal introns, presence of specific RNA sequence features associated with low translation efficiency, N1-methyladenosines in the early coding region, and enrichment for noncanonical binding by the EJC. Expand
A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies
TLDR
A DEAD-box helicase regulator has a novel role in centrosome and cilia function, ensuring proper pericentrin recruitment, microtubule organization, and ciliary beating and affects human development and disease mechanisms. Expand
Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation
TLDR
The results establish a unique molecular phenotype for the U2AF1 mutation which recapitulates translational mis-regulation in myeloid disease and results in a global increase in mRNA translation at the single cell level. Expand
How T cells go rogue in the absence of Roquins.
TLDR
Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity and their functions in Foxp3+ T regulatory cells are determined and novel mechanisms of Roquinmediated regulation of its target mRNAs are uncovered. Expand
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