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LL-BM123beta, gamma1 and gamma2 are three new antibiotics produced by fermentation of an unidentified species of Nocardia. These strongly basic, water soluble compounds were isolated from the culture filtrate by CM-Sephadex ion-exchange and carbon chromatography. All three antibiotics are active against both gram-positive and gram-negative bacteria. A(More)
Three tetracycline analogues, tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) have been used extensively in man and are well established as effective antimicrobial agents. Recently a fourth analogue, demethyl-chlortetracycline (DMCT) was described (1) and is being introduced for clinical use.' The structural formulas of these four(More)