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Glucan particles (GPs) are hollow, porous 2-4 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of soluble payloads (DNA, siRNA, protein, and small(More)
Successful submarine operations—those that accomplish the mission while maintaining security and safety—depend on numerous factors. Among the most critical elements driving success are the effectiveness of team behavior and the ability to understand when this behavior breaks down such that this degradation can be mitigated or avoided. While underway,(More)
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