Acute Q fever is an emergent and severe disease in French Guiana. We obtained 5 Coxiella burnetii isolates from samples of patients from Cayenne and found an epidemic clone circulating in Cayenne. This clone has caused pneumonia and endocarditis and seems to be more virulent than previously described strains.
BACKGROUND Until 2008, human rabies had never been reported in French Guiana. On 28 May 2008, the French National Reference Center for Rabies (Institut Pasteur, Paris) confirmed the rabies diagnosis, based on hemi-nested polymerase chain reaction on skin biopsy and saliva specimens from a Guianan, who had never travelled overseas and died in Cayenne after… (More)
OBJECTIVE To describe characteristics and outcomes of HIV-infected patients with Pneumocystis jirovecii pneumonia (PCP) over 2004-2011 in France, in particular in those previously enrolled (PE) in the French Hospital Database on HIV (FHDH). METHODS PE patients with an incident PCP were compared with patients with an inaugural PCP revealing HIV infection… (More)
OBJECTIVE To compare the time from entry into care for HIV infection until combination antiretroviral therapy (cART) initiation between migrants and non migrants in France, excluding late access to care. METHODS Antiretroviral-naïve HIV-1-infected individuals newly enrolled in the FHDH cohort between 2002-2010, with CD4 cell counts >200/μL and no previous… (More)
BACKGROUND To test the prognostic value of tumour protein and genetic markers in colorectal cancer (CRC) and examine whether deficient mismatch repair (dMMR) tumours had a distinct profile relative to proficient mismatch repair (pMMR) tumours. METHODS This prospective multicentric study involved 251 stage I-III CRC patients. Analysed biomarkers were EGFR… (More)
Objectives To compare virological outcomes in patients who switched to a cART including efavirenz (EFV), nevira-pine (NVP) or abacavir (ABC) with patients who continued on a first virologically successful boosted protease inhibitor (PI)-containing cART, and to assess virological differences between the switch regimens. Methods Using the French Hospital… (More)
BACKGROUND The purpose of this study was to compare parasacral and Winnie's single- or double-injection approaches for sciatic nerve block. METHODS One hundred fifty adults scheduled to undergo lower limb surgery were randomized to receive on the sciatic nerve 20 ml ropivacaine, 0.75%: single bolus for parasacral and Winnie's single injection. For… (More)