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OBJECTIVE To determine initial 24-week outcomes among prospectively enrolled patients with failure of initial antiretroviral therapy (ART). METHODS Baseline virologic failure was defined as HIV-1 viral load greater than 1000 copies/ml. Second-line ART was informed by results of genotype testing and selected from agents in the South-African public sector.(More)
This study investigated how chronic perinatal reduction of nerve growth factor (NGF) affected brain cholinergic markers in the two sexes. Rats received anti-NGF on postnatal days (PNDs) 2-12, and choline acetyltransferase (ChAT) activity was measured on PND 16. Anti-NGF significantly reduced cortical ChAT activity in males, but not in females; no(More)
BACKGROUND Stavudine continues to be used in antiretroviral treatment (ART) regimens in many resource-limited settings. The use of zidovudine instead of stavudine in higher-risk patients to reduce the likelihood of lactic acidosis and hyperlactatemia (LAHL) has not been examined. METHODS Antiretroviral-naïve, HIV-infected adults initiating ART between(More)
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