Aastha Sindhwani

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The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase Arl8b, but not Rab7 (also known as RAB7A), is essential(More)
HOmotypic fusion and Protein Sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome-lysosome fusion. However, little is known about how HOPS complex is recruited to lysosomes in mammalian cells. Here we report that the small GTPase Arl8b, but not Rab7, is essential for membrane localization of hVps41(More)
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