Aastha Sindhwani

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The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase Arl8b, but not Rab7 (also known as RAB7A), is essential(More)
HOmotypic fusion and Protein Sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome-lysosome fusion. However, little is known about how HOPS complex is recruited to lysosomes in mammalian cells. Here we report that the small GTPase Arl8b, but not Rab7, is essential for membrane localization of hVps41(More)
Lysosomes are dynamic organelles that not only mediate degradation of cellular substrates but also play critical roles in processes such as cholesterol homeostasis, plasma membrane repair, antigen presentation, and cell migration. The small GTPase Arl8, a member of Arf-like (Arl) family of proteins, has recently emerged as a crucial regulator of lysosome(More)
Salmonella enterica serovar typhimurium extensively remodels the host late endocytic compartments to establish its vacuolar niche within the host cells conducive for its replication, also known as the Salmonella-containing vacuole (SCV). By maintaining a prolonged interaction with late endosomes and lysosomes of the host cells in the form of interconnected(More)
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